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  • Expanding the CRISPR Toolbox

    Rough-and-ready Cas9 enzymes are powerful and popular CRISPR tools, but they’re hardly the be-all, end-all of genome editing

  • Could a CRISPR Therapeutic Cure Sickle-Cell Disease?

    CRISPR therapeutics for sickle-cell disease, says IDT, need fewer off-target effects and more on-target efficiency

  • No Side Effects in Small Trial

    Advanced cancer patients treated with immune cells that underwent CRISPR-mediated gene editing exhibited no serious side effects, New Scientist reports. It notes that concerns about the treatment particularly revolved around whether unintended CRISPR cuts occur and turn those cell…

  • CRISPR gene cuts may offer new way to chart human genome

    In search of new ways to sequence human genomes and read critical alterations in DNA, researchers say they have successfully used the gene cutting tool CRISPR to make cuts in DNA around lengthy tumor genes, which can be used to collect sequence information.

  • Translating Pharmacomicrobiomics: Three Actionable Challenges/Prospects in 2020

    The year 2020 marks a decade since the term pharmacomicrobiomics was coined (Rizkallah et al., 2010) to crystallize a century-old concept of mutual interactions between humans, drugs, and the microbial world. The human microbiome, with its immense metabolic potential that exceeds …

  • Defect in the ATP13A2 Gene Can Lead to Parkinson’s

    Researchers at KU Leuven have discovered that a defect in the ATP13A2 gene causes cell death by disrupting the cellular transport of polyamines. When this happens in the part of the brain that controls body movement, it can lead to Parkinson's disease. With more than six million p…

  • CRISPR Too Much of a Good Thing for Some Bacterial Species

    As a bacterial immune system, CRISPR-Cas is supposed to impose cuts, not suffer them. Yet CRISPR-Cas has been eliminated from many bacterial genomes. How this happens isn't exactly clear, particularly since the presence or absence of CRISPR-Cas systems among and even within bacter…

  • CRISPR-Nanopore Sequencing Combo Could Revolutionize Cancer Gene Identification

    The speed and accuracy w ith which current sequencing platforms can produce results are quite staggering compared to methodologies that were being utilized less than ten years ago. Yet, when it comes to making clinical decisions with respect to cancerous tumors, sequencing assays …

  • The first CRISPR gene therapy is safe

    In November, researchers announced the results of the first US CRISPR gene therapy. Now the data are out in a peer-reviewed paper, and here are comments on the results from leading researcher Carl June and experts in the field.