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  • Translating Pharmacomicrobiomics: Three Actionable Challenges/Prospects in 2020

    The year 2020 marks a decade since the term pharmacomicrobiomics was coined (Rizkallah et al., 2010) to crystallize a century-old concept of mutual interactions between humans, drugs, and the microbial world. The human microbiome, with its immense metabolic potential that exceeds …

  • Defect in the ATP13A2 Gene Can Lead to Parkinson’s

    Researchers at KU Leuven have discovered that a defect in the ATP13A2 gene causes cell death by disrupting the cellular transport of polyamines. When this happens in the part of the brain that controls body movement, it can lead to Parkinson's disease. With more than six million p…

  • CRISPR Too Much of a Good Thing for Some Bacterial Species

    As a bacterial immune system, CRISPR-Cas is supposed to impose cuts, not suffer them. Yet CRISPR-Cas has been eliminated from many bacterial genomes. How this happens isn't exactly clear, particularly since the presence or absence of CRISPR-Cas systems among and even within bacter…

  • CRISPR-Nanopore Sequencing Combo Could Revolutionize Cancer Gene Identification

    The speed and accuracy w ith which current sequencing platforms can produce results are quite staggering compared to methodologies that were being utilized less than ten years ago. Yet, when it comes to making clinical decisions with respect to cancerous tumors, sequencing assays …

  • The first CRISPR gene therapy is safe

    In November, researchers announced the results of the first US CRISPR gene therapy. Now the data are out in a peer-reviewed paper, and here are comments on the results from leading researcher Carl June and experts in the field.

  • Preliminary Results Point to Success of In Vivo Gene Editing

    Two studies show signs that the introduced DNA is functioning, but it’s too early to know if patients actually benefit.

  • Reproductive genome from the laboratory

    Synthetic biology researchers have developed a genome the size of a minimal cell that can copy itself.

  • Genome stability: Intricate process of DNA repair discovered

    An elaborate system of filaments, liquid droplet dynamics and protein connectors enables the repair of some damaged DNA in the nuclei of cells, researchers have found. The findings further challenge the belief that broken DNA floats aimlessly -- and highlight the value of cross-di…

  • Molecular 'switch' reverses chronic inflammation and aging

    Scientists have identified a molecular 'switch' that controls the immune machinery responsible for chronic inflammation in the body. The finding could lead to new ways to halt or even reverse many age-related conditions, from from Alzheimer's and Parkinson's to diabetes and cancer…