Human embryonic kidney 293 (HEK293, HEK-293, or HEK) cells are one of the most common cell lines used for research purposes, second only to HeLa cells. Their popularity is due to several properties such as easy maintenance, robustness, and ease of transfection. The history of HEK …
2020-03-25Researchers have used high-throughput screening of adeno-associated viral (AAV) vector capsid libraries to maximize the likelihood of obtaining AAV variants with desired properties. As a result of these experiments, they gained some unexpected insights, reported in an article publ…
2020-03-24EPO, an important drug for treating anemia, can now be produced in higher quantities and with better quality in mammalian cells designed using CRISPR.
2020-03-23Gene drives use genetic engineering to create a desired mutation in a few individuals that then spreads via mating throughout a population in fewer than 10 generations.
2020-03-20Researchers have developed a new kind of CRISPR screen technology to target RNA. The team leveraged their technology for a critical analysis: The COVID-19 public health emergency is due to a coronavirus, which contains an RNA - not DNA - genome.
2020-03-19NEW YORK – Recurrent "long tail," or less frequent, mutations that dial down the NOTCH signaling pathway appear to play a role in human head and neck squamous cell carcinoma (HNSCC) cases, new research suggests.
2020-03-17Doctors in Oregon delivered the gene editing machinery behind the retina in hopes of treating an inherited form of blindness, according to the companies that developed the therapy.
2020-03-16Barth syndrome is a rare metabolic disease in boys caused by mutation of a gene called tafazzin or TAZ. It can cause life-threatening heart failure and also weakens the skeletal muscles, undercuts the immune response, and impairs overall growth. There is no cure or specific treatm…
2020-03-13Using a novel single-cell RNA sequencing approach, a team from the Oncode Institute has uncovered new details about the rates of messenger RNA synthesis and degradation in mammalian cells.
2020-03-11