Using a technique called cryogenic electron microscopy (cryo-EM), a team of scientists from the United States and Canada has captured atomic-level, 3D images of the Cas9 enzyme before and after cutting the DNA. The images reveal new information about how the CRISPR-Cas9 gene-editi…
2019-08-14Biomedical engineers have developed a method for improving the accuracy of the CRISPR genome editing technology by an average of 50-fold. The approach adds a short tail to the guide RNA that folds back and binds onto itself, creating a 'lock' that can only be undone by the targete…
2019-08-14A cure for HIV has been one of the biggest challenges facing the scientific and medical communities for decades. The virus has managed to successfully evade almost every technique that has been thrown up against it. Not only can HIV mutate frequently—making new variants quickly …
2019-08-02Last month, the US Patent and Trademark Officereignited the infamous CRISPR patent disputewhen it declared interference—overlapping intellectual property—between several pending patents belonging to the University of California and patents already awarded to the Broad Institut…
2019-08-02In a pathbreaking experiment, a 34-year-old mother of four from Mississippi is in the limelight for volunteering to be the subject ofCRISPR-mediated gene editingin the hope of achieving a cure for the painful sickle cell anemia with which she has suffered all her life. 3D Renderin…
2019-08-02The new system, dubbed RESCUE, allows RNA edits to be made that were not previously possible.
2019-08-02Using the genome-editing system CRISPR, researchers at MIT and in China have engineered macaque monkeys to express a gene mutation linked to autism and other neurodevelopmental disorders in humans. These monkeys show some behavioral traits and brain connectivity patterns similar t…
2019-08-02