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  • Site-directed mutagenesis in wheat via haploid induction by maize

    A new study, which has recently been published in the Plant Biotechnology Journal , demonstrates how site-directed mutagenesis can be achieved in virtually any wheat germplasm of choice by intergeneric pollination of wheat with cas9/guide-RNA (gRNA)-transgenic maize. For exemplifi…

  • New CRISPR C-to-G DNA base editor expands the landscape of precision genome editing

    New genome-editing technologies developed by researchers in J. Keith Joung's laboratory at the Massachusetts General Hospital (MGH) have the potential to help understand disease-associated genetic mutations that are based on C-to-G (cytosine to guanine) single base changes. The ne…

  • Base editing is unquestionably one of the most exciting recent technology innovations in the field of

    Base editing is unquestionably one of the most exciting recent technology innovations in the field of genome editing. The development of these base editors in the lab of David Liu (Broad Institute/HHMI) enables the substitution of specific bases in DNA (C to T and A to G) without …

  • Megaphages harbor mini-Cas proteins ideal for gene editing

    The new Cas proteins were found in the largest known bacteria-infecting viruses, called bacteriophages, and are the most compact working Cas variants yet discovered -- half the size of today's workhorse, Cas9. Smaller and more compact Cas proteins are easier to ferry into cells to…

  • A bacterial toxin enables the first mitochondrial gene editor

    Bacterial weaponry has an unexpected use in human cells. A protein secreted by bacteria to kill other microbes has been re-engineered to tweak DNA inaccessible to other gene editors, scientists report online July 8 in Nature. The advance paves the way for one day fixing mutations …

  • New Gene Editing Tool Corrects Mutations in Mitochondrial DNA

    In a creative feat of molecular engineering, scientists have for the first time developed a gene editing tool capable of making targeted, single base pair changes in the DNA of mitochondria. The new editor, derived from a bacterial toxin, could allow researchers to better study mi…

  • Tiny Cas Protein, Huge Gene Editing Potential … Thanks, Megaphage!

    It helps to pack light, whether you’re a live virus or a gene editing vector. That’s why a travel-size version of a DNA-cutting enzyme that was found in a virus is of interest to genomic scientists. The enzyme, called CasΦ, is about half the size of Cas9, the most widely used…

  • Base Editor Converts “Wanted” Cs, Spares “Bystander” Cs

    “Round up the usual suspects!” This expression, which bespeaks expediency, could apply to the gene editing tools known as cytosine base editors (CBEs). CBEs, which are supposed to convert selected cytosines (Cs) in the human genome to thymines (Ts), may fail to distinguish bet…

  • Rapid Alzheimer’s Disease Drug Screening System Developed and Protective Gene Identified

    A Queen Mary University of London-led team of scientists harnessed induced pluripotent stem cell (iPSC) technology and hairs donated by individuals with Down syndrome (DS), to develop a rapid in vitro cell-based screening system that recapitulates the primary features of Alzheimer’…


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