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  • Genome Editing Helps Cell Lines “Clean Up” Their Protein Production

    If you want to "clean up" in the recombinant protein business, you might want to start by sweeping away process-related impurities, specifically, host cell proteins (HCPs). Undesirable HCPs are generated by host cells along with desirable biotherapeutic proteins, increasing metabo…

  • Mechanism of Checkpoint Protein Regulation Identified, Suggesting New Approaches to Boosting Cancer I

    Scientists at the University of Texas (UT) Southwestern Medical Center used CRISPR-based screening to help identify a mechanism by which cancer cells can regulate the production of a protein that suppresses immune system responses against the tumor. The team's combined studies in …

  • Researchers identify cells likely targeted by COVID-19 virus

    Researchers have identified specific types of cells that appear to be the targets of the SARS-Cov-2 coronavirus that is causing the Covid-19 pandemic.

  • Strategies for Optimizing CRISPR-Cas9 Delivery into Hard-to-Transfect Cells

    As a means of transfection, conventional electroporation has been limited by its toxic effects. A less toxic electroporation option has been developed by Lonza. This option, Nucleofector, encompasses instrumentation, solution/supplement kits, and optimized protocols. It can ad-dre…

  • When Alzheimer’s Tau Knocks, This Neuron Receptor Opens the Door

    Brain cells have no difficulty accommodating normal tau protein. In fact, tau protein maintains structure and stability within neurons, and it helps the transport of nutrients from one part of the cell to another. But abnormal tau protein is an unwelcome guest. By dint of its aber…

  • Researchers Move Closer to Industrial Production of Heparin in Cell Culture

    Scientists at the University of California-San Diego say they have moved one step closer to the ability to make heparin in cultured cells. Heparin is a potent anti-coagulant and the most prescribed drug in hospitals, yet cell-culture-based production of heparin is currently not po…

  • Bile metabolite of gut microbes boosts immune cells

    A new study has discovered a novel means by which bacterial colonies in the small intestine support the generation of regulatory T cells--immune cells that suppress autoimmune reactions and inflammation.

  • Trivalent CAR T Cells a Triple Threat to Leukemia Cells

    A trident can make spearfishing more of a sure thing. Similarly, a T cell engineered to brandish three prongs—chimeric antigen receptors (CARs)—can kill cancer cells more efficaciously than single-pronged or even double-pronged CAR T cells, let alone ordinary, unmodified T cel…

  • Diagnostics, meet CRISPR

    A new diagnostic test to quickly and easily monitor kidney transplant patients for infection and rejection relies on a simple urine sample and a powerful partner: the gene-editing technology CRISPR.


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