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NF-κB has constitutive activity in malignant tumor cells and tumor microenvironment, and is rarely activated due to the changes of its related genes. Therefore, NF-κB has become a great potential for tumor therapy. Ubigene offer nearly 2000 kinds of cell lines in stock, includin…
Wen Zhang et al.had found that CBT can suppresses colorectal cancer via enhancing the expression of multiple p53 downstream effector genes and promoting cell cycle arrest, apoptosis and inhibition of angiogenesis. Ubigene can provide hTP53 gRNA KO plasmids or TP53 knockout cell li…
[Research highlight] New target for NAFLD treatment--Metformin activates TFEB to induce autophagy Nonalcoholic fatty liver disease (NAFLD) is a major liver disease subtype , which is characterized by an excessive hepatic lipidaccumulation, covers a wide range of liver disorders, i…
[Research Highlight] mir-302a is involved in vascular smooth muscle cell proliferation and restenosis Vascular stenosis in different parts of body can lead to diseases of organs or tissues dominated by blood vessels in corresponding areas, such as Acute coronary syndrome (ACS) whi…
[Research highlight]A new target for human endometrial cancer treatment Human endometrial cancer (EC) is one of the malignant tumors of the female reproductive tract . With the increase of aging populations, obesity, and other metabolic diseases, as well as the delay of marriage a…