ABL2 Knockout cell line (RD)
Red cotton OmniCell bank
Overview
Ubigene gene knockout cell lines mediated by optimized CRISPR-Cas9 technology provide reliable in vitro models for investigating gene function, signaling pathways, disease mechanisms, and therapeutic targets.
ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase) encodes a non-receptor tyrosine kinase of the Abelson family. The protein contains SH2, SH3, and tyrosine kinase domains and regulates cytoskeletal organization through C-terminal interactions with F-actin and microtubules. ABL2 therefore contributes to intracellular signaling and cytoskeletal rearrangements that influence cell morphology and movement.
A human embryonal rhabdomyosarcoma cell line derived from a malignant tumor in a 7-year-old female. The cell line has also been designated TE 32 and 130T in the literature.
Comprehensive quality control includes STR authentication, sterility testing (bacteria and fungi), and mycoplasma screening to ensure purity and performance. Genotype is confirmed by two rounds of PCR and Sanger sequencing, and complete validation reports are provided for make-to-order products.
Product Overview
Key Advantages
Cas9 cell lines in our cell bank can stably express Cas9 protein. Each Cas9 Stable Cell Line is easy to use and enables gene knockout simply by transfecting gRNA, while transfection of gRNA and donor DNA results in gene knock-in or point mutations
These Cas9 stable cell lines have been used to construct the KO cell lines for various genes, gene KO efficiency 5-10 times improved.
Selected cells, low passages, good cell condition, high activity, applicable for all kinds of gene-editing experiments.
Quality Control Specifications
Knockout Region: E5
Reference Transcript: ABL2-203
Validation Method: PCR amplification+Sanger sequencing
Download STR ReportIntended use
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use
Unpacking and Storage Instructions
Handling procedure
References
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