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A Novel Mechanism where Vitamin C Targets ACSL4 to Alleviate Primate Aging

Explore the novel "ferro-aging" mechanism and the central role of ACSL4 in lipid peroxidation. This study reveals how Vitamin C acts as a targeted inhibitor to alleviate aging in primates, offering a new paradigm for anti-aging interventions.

Vascular STING Signaling Regulates NK Cell Infiltration in Small Cell Lung Cancer

Uncovering how vascular STING signaling drives NK cell recruitment and enhances CAR-NK cell therapy in small cell lung cancer.

Targeting LRRC15⁺ CAFs to Suppress Lung Cancer | Research Frontier

Discover how LRRC15⁺ CAFs drive lung cancer progression. This study reveals a new therapeutic target and a bispecific antibody to enhance immune response.

CRISPR Screens Identify RARA/SPNS1 in Doxorubicin Cardiotoxicity

Genome-wide CRISPR screens identify RARA and SPNS1 as key regulators of Doxorubicin cardiotoxicity, providing new therapeutic targets for heart safety.

CRISPR Screening Identifies OR7A10 as a Key Enhancer for CAR-NK Cell Therapy in Solid Tumors

CRISPR screening identifies OR7A10 as a key enhancer for CAR-NK therapy in solid tumors, improving cytotoxicity, persistence, and tumor infiltration.

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