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Case Study (63)
Expert Insights - Cell Culture (22)
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Expert Insights - CRISPR Library (42)
Gene Editing Practical Tips (25)
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The m6A-YTHDF1-NOTCH1 Axis Promotes Colorectal Cancer Stemness and Drug Resistance

YTHDF1 enhances NOTCH1 translation via m6A modification, promoting cancer stemness and chemoresistance in colorectal cancer.

Expert Insights | Practical Tips for HTR-8/SVneo Cell Culture and Gene Editing

Comprehensive HTR-8/SVneo cell culture and gene editing guide covering thawing, passaging, cryopreservation, transfection optimization, lentiviral transduction, single-cell cloning, and troubleshooting tips.

Breaking Therapeutic Barriers: CRISPR Screens Identify Core Targets, GSK3β Inhibitors Strike at B-ALL Survival

CRISPR loss-of-function screening identifies β-catenin degradation as a survival dependency in B-ALL. GSK3β inhibitors induce MYC suppression and selective leukemia cell death.

Research Frontier | Uridine Emerges as a Potential Anticancer “Game Changer”?

SNX17 promotes uridine depletion and suppresses CD45 N-glycosylation, impairing CD8⁺ T cell function and driving ICB resistance. Uridine supplementation restores antitumor immunity and enhances PD-1 therapy.

IF=14.9 | LOTI Gene Editing: Efficient & Precise In Vivo Knock-In

The LOTI (Long-Offset Paired Nicking–based Target Integration) strategy introduces long-offset nicks in both genomic and donor DNA using Cas9 nickase, achieving highly efficient and precise in vivo integration of large DNA fragments and restoring coagulation function in hemophilia B mice, advancing gene therapy applications.

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