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IF=14.9 | LOTI Gene Editing: Efficient & Precise In Vivo Knock-In

The LOTI (Long-Offset Paired Nicking–based Target Integration) strategy introduces long-offset nicks in both genomic and donor DNA using Cas9 nickase, achieving highly efficient and precise in vivo integration of large DNA fragments and restoring coagulation function in hemophilia B mice, advancing gene therapy applications.

Acetate in Cancer: Driving Tumor Growth and Immune Evasion

Discover how acetate, a common metabolite, fuels tumor growth and promotes immune evasion via the MCT1 → ACSS2 → DLAT → USP10 → c-Myc pathway. Learn about novel therapeutic targets and strategies combining metabolic intervention with immunotherapy.

Breaking Therapy Resistance! CRISPR Transcription Factor Library Identifies SMAD1 as a Key Driver of Paneth-like Transition in Colorectal Cancer

CRISPR transcription factor screening identifies SMAD1-driven Paneth-like transition as a key mechanism of KRAS/EGFR resistance in CRC.

Nature Genetics (IF: 29) | p53 Inactivation Drives Breast Cancer Brain Metastasis

A Nature Genetics study reveals that p53 inactivation drives breast cancer brain metastasis by upregulating SCD1 and fatty acid metabolism, identifying new therapeutic vulnerabilities.

Point Mutation Cell Line Generation: 4 Core Methods & Applications

Learn how to generate point mutation cell lines using RNP, base editing, prime editing, and HDR-based methods. Covers principles, use cases, and strategy selection.

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