Apoa1 Knockout cell line (AML12)

Gene knockout cell lines are generated using CRISPR-Cas9 based technology to precisely disrupt target genes, enabling functional genomics research, disease modeling, and target validation.

Arid2 (AT-rich interaction domain 2) encodes a predicted component of SWI/SNF-related chromatin-remodeling complexes, including the BAF complex, and is associated with transcriptional regulation. It is implicated in embryonic organ development, heart development, and homeostatic processes. Arid2 is expressed in the central nervous system, early conceptus, and genitourinary system. Its human ortholog, ARID2, is associated with Coffin-Siris syndrome 6, colorectal cancer, and hepatocellular carcinoma.

AML12 (alpha mouse liver 12) is a mouse hepatocyte-derived cell line established from hepatocytes of a transgenic CD1 mouse expressing human transforming growth factor alpha (TGF-α). The cell line represents a non-tumorigenic liver cell model and is used for studies of hepatocyte biology, liver metabolism, and molecular mechanisms regulating hepatic function.

Before delivery, each clone is authenticated by STR, tested for sterility and mycoplasma, and genotype‑verified by two‑round PCR‑sequencing. Comprehensive QC data accompany every shipment to support reproducible research.