Apob Knockout cell line (TM4)
Red cotton OmniCell bank
Overview
CRISPR knockout cell lines are engineered through targeted genome editing to eliminate gene function, supporting studies of cellular biology, disease mechanisms, and drug discovery.
APOBR (apolipoprotein B receptor) encodes a macrophage receptor that binds apolipoprotein B-48 on dietary triglyceride-rich lipoproteins. This receptor may facilitate the uptake of lipids, fat-soluble vitamins, and other nutrients by reticuloendothelial cells. When circulating triglyceride-rich lipoproteins are elevated, excessive receptor-mediated uptake may contribute to foam cell formation, endothelial dysfunction, and atherothrombosis.
A murine Sertoli cell line derived from primary Sertoli cell-enriched preparations from the normal testes of 11–13-day-old BALB/c nu/+ mice. The cells respond to follicle-stimulating hormone (FSH) but not luteinizing hormone (LH), and FSH and retinoic acid stimulate plasminogen activator secretion.
Before delivery, each clone is authenticated by STR, tested for sterility and mycoplasma, and genotype‑verified by two‑round PCR‑sequencing. Comprehensive QC data accompany every shipment to support reproducible research.
Product Overview
Key Advantages
Cas9 cell lines in our cell bank can stably express Cas9 protein. Each Cas9 Stable Cell Line is easy to use and enables gene knockout simply by transfecting gRNA, while transfection of gRNA and donor DNA results in gene knock-in or point mutations
These Cas9 stable cell lines have been used to construct the KO cell lines for various genes, gene KO efficiency 5-10 times improved.
Selected cells, low passages, good cell condition, high activity, applicable for all kinds of gene-editing experiments.
Quality Control Specifications
Download STR ReportIntended use
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use
Unpacking and Storage Instructions
Handling procedure
References
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