STAT1 Knockout cell line (VERO C1008 (E6))

Gene knockout cell lines are generated using CRISPR-Cas9 based technology to precisely disrupt target genes, enabling functional genomics research, disease modeling, and target validation.

Stat1 (signal transducer and activator of transcription 1) encodes a transcription factor that mediates signaling through the JAK-STAT pathway and regulates gene expression in response to extracellular signals. It contributes to defense responses against pathogens, cell population proliferation, and the regulation of apoptosis. Stat1 functions in both the cytoplasm and nucleus and participates in responses to exogenous double-stranded RNA. Its human ortholog is associated with several cancers and inherited immunodeficiencies.

VERO C1008 (E6) is a subclone of the Vero76 cell line, which was originally derived from the kidney of an African green monkey. The cells retain susceptibility to a range of viruses and exhibit some degree of contact inhibition, making them suitable for supporting the growth and study of slowly replicating viruses. VERO C1008 (E6) is widely used in virology research, including viral propagation, infection studies, and evaluation of viral replication.

Comprehensive quality control includes STR authentication, sterility testing (bacteria and fungi), and mycoplasma screening to ensure purity and performance. Genotype is confirmed by two rounds of PCR and Sanger sequencing, and complete validation reports are provided for make-to-order products.