Syk Knockout cell line (BV2)

Gene knockout cell lines are generated using CRISPR-Cas9 based technology to precisely disrupt target genes, enabling functional genomics research, disease modeling, and target validation.

The BV2 cell line is a widely utilized murine microglial model derived from v-raf/v-myc-immortalized neonatal mouse microglia. Characterized as a premier in vitro system for investigating central nervous system (CNS) pathophysiology, this model effectively retains critical morphological and functional features of primary microglia. Biochemically and phenotypically reactive, BV2 cells serve as a robust discovery platform for studying neuroinflammation pathways, neurodegenerative disease progression, and immune responses via active cytokine production, phagocytosis, and direct sensitivity to inflammatory stimuli.

Before delivery, each clone is authenticated by STR, tested for sterility and mycoplasma, and genotype‑verified by two‑round PCR‑sequencing. Comprehensive QC data accompany every shipment to support reproducible research.