ZC3H12A Knockout cell line (THP-1)

CRISPR knockout cell lines are engineered through targeted genome editing to eliminate gene function, supporting studies of cellular biology, disease mechanisms, and drug discovery.

ZC3H12A (zinc finger CCCH-type containing 12A) encodes a CCCH-type zinc finger protein that has been described as an MCP1-induced transcriptional regulator. The protein has been implicated in activation of gene expression and induction of cardiomyocyte cell death, potentially through regulation of apoptosis-associated genes. Its biological activities suggest a role in transcriptional regulation and cellular survival, although the molecular mechanisms underlying these effects remain incompletely characterized.

THP-1 is a human monocytic leukemia cell line established from the peripheral blood of a 1-year-old male patient with acute monocytic leukemia at relapse. The cells exhibit monocytic characteristics, including expression of Fc and complement receptors, lysozyme production, esterase activity, and phagocytic capacity. THP-1 cells can be differentiated into macrophage-like cells under appropriate stimulation and are widely used as a model for studying monocyte/macrophage biology, immune responses, inflammation, differentiation, and host–pathogen interactions.

Before delivery, each clone is authenticated by STR, tested for sterility and mycoplasma, and genotype‑verified by two‑round PCR‑sequencing. Comprehensive QC data accompany every shipment to support reproducible research.