ZCCHC7 Knockout cell line (NCI-H1299)

CRISPR knockout cell lines are engineered through targeted genome editing to eliminate gene function, supporting studies of cellular biology, disease mechanisms, and drug discovery.

ZCCHC7 (zinc finger CCHC-type containing 7) encodes a zinc finger-containing protein with RNA-binding activity. It is predicted to participate in nuclear RNA surveillance, suggesting a role in monitoring and processing RNA molecules within the cell. ZCCHC7 is associated with the cytosol and nucleolus, although the specific molecular mechanisms and biological functions through which it contributes to RNA surveillance remain incompletely characterized.

NCI-H1299 is a human non-small cell lung cancer cell line established from a lymph node metastasis of the lung from a patient who had previously received radiation therapy. The cell line represents a metastatic lung cancer model and is commonly used in studies of lung cancer biology, tumor progression, and molecular mechanisms underlying cancer development.

Before delivery, each clone is authenticated by STR, tested for sterility and mycoplasma, and genotype‑verified by two‑round PCR‑sequencing. Comprehensive QC data accompany every shipment to support reproducible research.