ZFP36L2 Knockout cell line (NCI-H1299)

Ubigene gene knockout cell lines mediated by optimized CRISPR-Cas9 technology provide reliable in vitro models for investigating gene function, signaling pathways, disease mechanisms, and therapeutic targets.

ZFP36L2 (ZFP36 like 2 zinc finger CCCH-type) encodes a member of the TIS11 family containing a characteristic CCCH-type zinc finger domain. It is proposed to function in regulation of cellular responses to growth factors and other extracellular stimuli, although its precise molecular mechanisms remain incompletely characterized. ZFP36L2 is relevant to studies of zinc finger protein function, gene-expression regulation, growth-factor responses, and cellular signaling.

NCI-H1299 is a human non-small cell lung cancer cell line established from a lymph node metastasis of the lung from a patient who had previously received radiation therapy. The cell line represents a metastatic lung cancer model and is commonly used in studies of lung cancer biology, tumor progression, and molecular mechanisms underlying cancer development.

Comprehensive quality control includes STR authentication, sterility testing (bacteria and fungi), and mycoplasma screening to ensure purity and performance. Genotype is confirmed by two rounds of PCR and Sanger sequencing, and complete validation reports are provided for make-to-order products.