ZNF507 Knockout cell line (HCT-15)

Ubigene gene knockout cell lines mediated by optimized CRISPR-Cas9 technology provide reliable in vitro models for investigating gene function, signaling pathways, disease mechanisms, and therapeutic targets.

ZNF507 (zinc finger protein 507) encodes a zinc finger protein predicted to bind DNA and zinc ions and to positively regulate RNA polymerase II-dependent transcription. The protein is predicted to function in the nucleus, consistent with a role in transcriptional regulation. Although its specific target genes and molecular mechanisms remain incompletely characterized, ZNF507 may contribute to control of gene expression through sequence-specific DNA interactions.

HCT-15 is a human colorectal adenocarcinoma cell line established from a colorectal tumor. The cells are tumorigenic in nude mice and share a common genetic origin with several colorectal cancer cell lines, including DLD-1, HCT-8, and HRT-18, as confirmed by STR profiling. HCT-15 is widely used as a model for studying colorectal cancer biology, tumorigenesis, genetic alterations, and anticancer drug responses.

Before delivery, each clone is authenticated by STR, tested for sterility and mycoplasma, and genotype‑verified by two‑round PCR‑sequencing. Comprehensive QC data accompany every shipment to support reproducible research.