ZNF606 Knockout cell line (HEK293-A)
Red cotton OmniCell bank
Overview
CRISPR knockout cell lines are engineered through targeted genome editing to eliminate gene function, supporting studies of cellular biology, disease mechanisms, and drug discovery.
ZNF606 (zinc finger protein 606) encodes a KRAB-containing zinc finger protein with contiguous C2H2 zinc finger motifs. The nuclear protein can repress growth factor-mediated signaling and interacts with SOX9, suppressing its transcriptional activity by inhibiting DNA binding. Reduced ZNF606 expression promotes chondrocyte differentiation, indicating a role in transcriptional regulation and control of cell differentiation.
Comprehensive quality control includes STR authentication, sterility testing (bacteria and fungi), and mycoplasma screening to ensure purity and performance. Genotype is confirmed by two rounds of PCR and Sanger sequencing, and complete validation reports are provided for make-to-order products.
Product Overview
Key Advantages
Cas9 cell lines in our cell bank can stably express Cas9 protein. Each Cas9 Stable Cell Line is easy to use and enables gene knockout simply by transfecting gRNA, while transfection of gRNA and donor DNA results in gene knock-in or point mutations
These Cas9 stable cell lines have been used to construct the KO cell lines for various genes, gene KO efficiency 5-10 times improved.
Selected cells, low passages, good cell condition, high activity, applicable for all kinds of gene-editing experiments.
Quality Control Specifications
Targeted knockout region: EExon 5
Reference Transcript: NM_025027
Frameshift Mutation Strategy
Download STR ReportIntended use
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use
References
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