ZNF695 Knockout cell line (A-375)

Ubigene gene knockout cell lines mediated by optimized CRISPR-Cas9 technology provide reliable in vitro models for investigating gene function, signaling pathways, disease mechanisms, and therapeutic targets.

ZNF695 (zinc finger protein 695) encodes a predicted zinc finger transcription factor with sequence-specific DNA-binding activity associated with RNA polymerase II-regulated transcription. Its nuclear localization is consistent with a role in regulation of DNA-templated gene expression. However, current functional annotation does not identify specific target genes or downstream biological pathways regulated by ZNF695. Its molecular interactions and broader physiological functions therefore remain incompletely characterized.

The A375 cell line is a highly characterized human malignant melanoma model derived from a 54-year-old female patient. As referenced in image_2f51f1.png, this adherent cell line demonstrates robust translational performance in in vivo xenograft studies, reliably producing rapidly growing amelanotic melanomas when inoculated into anti-thymocyte serum-treated NIH Swiss mice. Serving as a globally recognized preclinical oncology platform, it is extensively utilized for investigating melanoma disease progression, executing high-throughput screening of novel therapeutics, and studying targeted signaling pathways in skin cancers.

Before delivery, each clone is authenticated by STR, tested for sterility and mycoplasma, and genotype‑verified by two‑round PCR‑sequencing. Comprehensive QC data accompany every shipment to support reproducible research.