FCGR3A Stable Expression Cell Line (A375)
Red cotton OmniCell bank
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use. | Sample Name | hFCGR3A-1CтMean | β-h_actinCтMean | ΔCтMean | ΔΔCт | Expression Rate |
|---|---|---|---|---|---|
| FCGR3A Stable Expression Cell Line (A375) | 16.67 | 16.442 | 0.228 | -14.021 | 16624.231 |
| A375_Ctrl(Puro) | 30.783 | 16.534 | 14.249 | 0.000 | 1.000 |
Intended use
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use
Unpacking and Storage Instructions
Handling procedure
Product Advantage
Cas9 cell lines in our cell bank can stably express Cas9 protein. Each Cas9 Stable Cell Line is easy to use and enables gene knockout simply by transfecting gRNA, while transfection of gRNA and donor DNA results in gene knock-in or point mutations
These Cas9 stable cell lines have been used to construct the KO cell lines for various genes, gene KO efficiency 5-10 times improved.
Selected cells, low passages, good cell condition, high activity, applicable for all kinds of gene-editing experiments.
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