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This article introduces how to use CRISPR libraries to discover ferroptosis targets such as FSP1, GCH1 and DHCR7. And more targets can be found using Ubigene's new technology CRISPR-iScreenTM .
In this study, PPP1R12B, KCNJ12, FGA knockout cells and overexpression lentiviruses carrying mutations constructed by Ubigene were used to detailed functional verification of three newly identified potential driver events which in the Chinese Liver Cancer Atlas (CLCA).
In this study, EGFP-OX40L overexpressing stable cells constructed by Ubigene were used to develop a novel engineered M1-like macrophage exosomeOX40L M1-exos for cancer immunotherapy.
In this study, CRISPR-Cas9 PRDX5 knockout 22Rv1 cells and LNCaP cells with lentiviral overexpression of PRDX5 gene constructed by Ubigene were used to discover the new mechanism of PRDX5 affecting the progress of castration-resistant prostate cancer (CRPC) by regulating redox
E.coli ATCC 25922 with recA and ldhA knockout as a key model confirmed dietary D-xylose can effectively reduce the pathogenic E.coli survival in the gut by activating prophages